[A case of allergic granulomatosis and angiitis (Churg-Strauss syndrome) in a 15-year-old girl].

Abstract

A 15-year-old girl with a 6-month history of bronchial asthma was admitted to our hospital because of fever, dyspnea, weight loss, dysesthesia, muscle weakness, gait disturbance and purpuric rash. In addition, leukocytosis, hypereosinophilia and elevation of CRP were observed. Chest radiograph and computed tomography on admission showed non-segmental patchy air-space consolidation in both lung fields. Skin biopsy was performed and the pathologic diagnosis was necrotizing arteritis with eosinophilic infiltration. Transbronchial lung biopsy revealed eosinophilic pneumonia. From the clinical course, laboratory data and pathologic findings, the diagnosis of allergic granulomatosis and angiitis (Churg-Strauss syndrome) was made. Following the skin and lung biopsies, intravenous pulse corticosteroid and oral prednisolone treatment was started and her clinical findings improved. Angiitis with allergic granulomatosis is a vasculitis that is found in adults. This is an extremely rare and interesting case of angiitis with allergic granulomatosis in childhood.

• Authors: Kazue Fujita, Kenji Yamato, Takeyuki Kurihara, Kohichi Osaki, Hideo Ohba, Junichi Nakamura, Niro Okimoto
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 42 Issue 9 Pg. 842-7 (Sep 2004) ISSN: 1343-3490 [Print] Japan
• PMID: 15500154 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Prednisolone

Topics

• Adolescent
• Anti-Inflammatory Agents (administration & dosage)
• Churg-Strauss Syndrome (diagnosis, drug therapy, pathology)
• Diagnosis, Differential
• Female
• Humans
• Prednisolone (administration & dosage)
• Radiography, Thoracic
• Tomography, X-Ray Computed