Experimental study of the use of Perftoran for preventing the formation of postoperative adhesions in peritonitis.

Abstract

The effect of Perftoran (perfluorocarbon compound) on cells of the peritoneal exudate and small intestinal serosa was studied in Wistar rats with experimental peritonitis and mechanical injury. The peritoneal cavity was treated with Perftoran for preventing postoperative adhesions and the mechanisms of reparative regeneration of the mesothelium after this treatment were studied by immunohistochemical methods and scanning electron microscopy. The increase in macrophage population during the early postoperative period and its decrease at later terms prevented fibroblast activation and promoted epithelialization as early as by day 5.

• Authors: I V Yarema, M A Magomedov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 136 Issue 6 Pg. 582-4 (Dec 2003) ISSN: 0007-4888 [Print] United States
• PMID: 15500078 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Fluorocarbons
• perftoran

Topics

• Animals
• Cell Division (drug effects)
• Exudates and Transudates (cytology, drug effects)
• Fibroblasts (drug effects)
• Fluorocarbons (therapeutic use)
• Immunohistochemistry
• Lymphocytes (drug effects)
• Macrophages (drug effects)
• Mast Cells (drug effects)
• Mesoderm (pathology, ultrastructure)
• Peritoneum (surgery)
• Peritonitis (drug therapy, pathology, physiopathology)
• Postoperative Complications (physiopathology, prevention & control)
• Rats
• Rats, Wistar
• Time Factors
• Tissue Adhesions (pathology, physiopathology, prevention & control)