[The effect of hepatoprotectors containing phospholipids on rats with experimental acute pancreatitis].

Abstract

The experiments on rats with a model acute pancreatitis showed that hepatoprotectors containing phospholipids (eplir and essentiale) improve the parameters of metabolism and the functions and histological characteristics of the pancreas and liver. Both drugs produced an antioxidant effect, decreased the activity of alpha-amylase, lipase, enzymes of hepatic origin in the blood, and reduced the content of creatinine, glucose, urea, bilirubin, and lipids. The therapeutic action of eplir was more pronounced than that of essentiale.

• Authors: A S Saratikov, A I Vengerovskiĭ, M E Mozzhelin, I V Sukhodolo
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2004 Jul-Aug Vol. 67 Issue 4 Pg. 35-7 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Terapevticheskiĭ éffekt gepatoprotektorov, soderzhashchikh fosfolipidy, pri éksperimental'nom ostrom pankreatite.
• PMID: 15500043 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Drug Combinations
• Enzymes
• Phosphatidylcholines
• Phospholipids
• eplir
• essential 303 forte
• Carotenoids

Topics

• Acute Disease
• Animals
• Antioxidants (pharmacology, therapeutic use)
• Carotenoids (pharmacology, therapeutic use)
• Drug Combinations
• Enzymes (blood)
• Liver (drug effects, enzymology, metabolism)
• Pancreas (drug effects, enzymology, metabolism)
• Pancreatitis (drug therapy, enzymology, metabolism)
• Phosphatidylcholines (pharmacology, therapeutic use)
• Phospholipids (pharmacology, therapeutic use)
• Rats