Abstract | BACKGROUND: METHODS: Plasma DNA was extracted with a QIAamp DNA Blood Midi kit and quantified by a PicoGreen dsDNA quantitation kit in 44 healthy individuals, 36 benign lung disease patients and 67 lung cancer patients. Discrimination power was evaluated by the receiver operating characteristic curve. RESULTS: Plasma DNA values were significantly increased in lung cancer patients, especially in those with metastases, and in benign lung disease patients compared with that in the healthy individuals (P < 0.001, respectively). The values in lung cancer patients were significantly increased compared with that in the benign lung disease patients (P < 0.001). The area under the curve was 0.96 [95% confidence interval (CI) 0.92 - 0.99] for the healthy versus lung cancer, 0.73 (95% CI 0.64 - 0.83) for lung cancer versus benign lung disease, and 0.86 (95% CI 0.80 - 0.91) for lung cancer versus the healthy and benign lung disease. CONCLUSIONS:
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Authors | Guang-shun Xie, Ai-rong Hou, Long-yun Li, Yan-ning Gao, Shu-jun Cheng |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 117
Issue 10
Pg. 1485-8
(Oct 2004)
ISSN: 0366-6999 [Print] China |
PMID | 15498370
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- DNA
(blood)
- Humans
- Lung Neoplasms
(blood, diagnosis, pathology)
- Neoplasm Staging
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