Abstract |
The chemical investigation of the cytotoxic and antituberculosis active MeOH crude extract of the marine sponge Pachychalina sp. led to the isolation of six new nitrogenous metabolites, including ingenamine G (1), as well as a mixture of new cyclostellettamines G, H, I, K, and L (10-14) with the known cyclostellettamines A- F (4-9). Structural assignments of compound 1 were based on the analysis of MS and NMR data, while the structures of compounds 10-14 could be established by HPLC-MS/MS analysis. Ingenamine G displayed cytotoxic activity against HCT-8 (colon), B16 ( leukemia), and MCF-7 ( breast) cancer cell lines, antibacterial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and four oxacilin-resistant S. aureus strains, and antimycobacterial activity against Mycobacterium tuberculosis H37Rv.
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Authors | Jaine H H L de Oliveira, Achim Grube, Matthias Köck, Roberto G S Berlinck, Mario L Macedo, Antonio G Ferreira, Eduardo Hajdu |
Journal | Journal of natural products
(J Nat Prod)
Vol. 67
Issue 10
Pg. 1685-9
(Oct 2004)
ISSN: 0163-3864 [Print] United States |
PMID | 15497940
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Alkaloids
- Anti-Bacterial Agents
- Antineoplastic Agents
- Antitubercular Agents
- Heterocyclic Compounds, 4 or More Rings
- ingenamine G
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Topics |
- Alkaloids
(chemistry, isolation & purification, pharmacology)
- Animals
- Anti-Bacterial Agents
(chemistry, isolation & purification, pharmacology)
- Antineoplastic Agents
(chemistry, isolation & purification, pharmacology)
- Antitubercular Agents
(chemistry, isolation & purification, pharmacology)
- Brazil
- Drug Screening Assays, Antitumor
- Escherichia coli
(drug effects)
- Heterocyclic Compounds, 4 or More Rings
(chemistry, isolation & purification, pharmacology)
- Humans
- Microbial Sensitivity Tests
- Molecular Structure
- Mycobacterium tuberculosis
(drug effects)
- Porifera
(chemistry)
- Staphylococcus aureus
(drug effects)
- Tumor Cells, Cultured
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