Abstract | BACKGROUND: METHODS: RESULTS: Serum growth hormone levels failed to correlate with age (r2 = 3.03) in the entire group of normal subjects (i.e. 20 - 80 years). In contrast, serum insulin-like growth factor-1 levels were inversely correlated with age (adjusted r2 = 0.092). Of note, serum growth hormone was positively correlated with age (adjusted r2 = 0.269) in the 20 - 46 year range which overlapped with the age range of patients in the systemic lupus erythematosus group. In that regard, serum growth hormone levels were not significantly higher compared to either the entire group of normal subjects (20 - 80 yrs) or to normal subjects age-matched to the systemic lupus erythematosus patients. Serum insulin-like growth factor-1 levels were significantly elevated (p < 0.001) in systemic lupus erythematosus patients, but only when compared to the entire group of normal subjects. Serum somatostatin levels differed from normal subjects only in older (i.e. >55 yrs) systemic lupus erythematosus patients. CONCLUSIONS:
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Authors | Charles W Denko, Charles J Malemud |
Journal | BMC musculoskeletal disorders
(BMC Musculoskelet Disord)
Vol. 5
Issue 1
Pg. 37
(Oct 20 2004)
ISSN: 1471-2474 [Electronic] England |
PMID | 15496230
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Somatostatin
- Insulin-Like Growth Factor I
- Growth Hormone
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Topics |
- Adult
- Age Factors
- Female
- Growth Hormone
(blood)
- Humans
- Insulin-Like Growth Factor I
(metabolism)
- Lupus Erythematosus, Systemic
(blood)
- Middle Aged
- Regression Analysis
- Somatostatin
(blood)
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