Clinical and endocrine aspects of pituitary tumors.

Abstract

OBJECTIVE:

To study the clinical spectrum and endocrine profile of pituitary tumors presenting to a tertiary care endocrine center.

METHODS:

Retrospective analysis of clinical and hormonal data of patients with pituitary tumors admitted in the Endocrinology Department of Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir India between January 1989 and December 1998.

RESULTS:

Over a period of one decade, 75 subjects were diagnosed to have pituitary tumors. Somatotroph adenoma was the most common pituitary mass lesion seen (44/75) and followed in the decreasing order of frequency, by non-functioning pituitary tumor (12/75), prolactinoma (11/75) and corticotroph adenoma (8/75). Overall there was a male preponderance (male to female ratio was 41:34). Subjects with somatotroph adenoma presented with classical features of acromegaly: mean fasting and post glucose suppression growth hormone levels were 34.04+/-11.67 and 36.47+/-6.64 ng/ml. Eleven subjects (9 females and 2 males) had prolactinoma; females presented with the classical symptom complex of amenorrhea-galactorrhea while males presented with headache, visual disturbances and impotence. The 12 subjects with nonfunctioning pituitary tumors presented with features of mass lesion. Of the 8 subjects (6 females and 2 males) with corticotroph adenomas, 2 were confirmed to have periodic hormonogenesis.

CONCLUSION:

In an endocrine center, functioning pituitary tumors are more often seen than non-functioning tumors.

• Authors: Abdul H Zargar, Bashir A Laway, Shariq R Masoodi, Mohammad Salahuddin, Mohammad A Ganie, Mohammad H Bhat, Arshad I Wani, Mir I Bashir
• Journal: Saudi medical journal (Saudi Med J) Vol. 25 Issue 10 Pg. 1428-32 (Oct 2004) ISSN: 0379-5284 [Print] Saudi Arabia
• PMID: 15494816 (Publication Type: Comparative Study, Journal Article)

Topics

• Adenoma (diagnosis, epidemiology, therapy)
• Adenoma, Chromophobe (diagnosis, epidemiology, therapy)
• Adolescent
• Adult
• Age Distribution
• Aged
• Female
• Humans
• India (epidemiology)
• Male
• Middle Aged
• Pituitary Neoplasms (diagnosis, epidemiology, therapy)
• Prevalence
• Prognosis
• Prolactinoma (diagnosis, epidemiology, therapy)
• Retrospective Studies
• Risk Assessment
• Severity of Illness Index
• Sex Distribution
• Survival Rate