Adjunctive granulocyte colony-stimulating factor therapy for diabetic foot infections.

Abstract

OBJECTIVE:

To evaluate the role of granulocyte colony-stimulating factor (G-CSF) as adjunctive therapy for the treatment of diabetic foot infections in non-neutropenic patients.

DATA SOURCES:

Clinical literature was accessed through MEDLINE (1965-April 2004). Key search terms included G-CSF, infection, and diabetes. In addition, relevant references from primary and secondary article bibliographies were extracted.

DATA SYNTHESIS:

Three clinical trials evaluating G-CSF for diabetic foot infections were identified. These data demonstrated positive effects of G-CSF on improvement of foot infections and risk of amputations.

CONCLUSIONS:

Controlled trials are necessary to validate the role of adjunctive G-CSF at reducing amputations in patients with diabetic foot infections.

• Authors: Kelly S Reed, Manjunath P Pai
• Journal: The Annals of pharmacotherapy (Ann Pharmacother) Vol. 38 Issue 12 Pg. 2150-3 (Dec 2004) ISSN: 1060-0280 [Print] United States
• PMID: 15494384 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Infective Agents
• Hematinics
• Granulocyte Colony-Stimulating Factor

Topics

• Anti-Infective Agents (therapeutic use)
• Diabetic Foot (drug therapy)
• Drug Therapy, Combination
• Granulocyte Colony-Stimulating Factor (therapeutic use)
• Hematinics (therapeutic use)
• Humans
• Randomized Controlled Trials as Topic
• Treatment Outcome