Abstract | BACKGROUND:
Sulthiame is a central carbonic anhydrase inhibitor found to be effective for both partial and generalized seizures. It has been in use in some European countries and in Israel for over 30 years. The aim of the present study was to evaluate the efficacy and tolerability of sulthiame in childhood epilepsy by conducting a multicenter, retrospective study of patients who received this drug. METHODS: RESULTS: Twenty-nine out of 39 patients with benign focal epilepsy of childhood became seizure-free. Total seizure control was also achieved in 17 of 42 patients with symptomatic, non-refractory localization-related epilepsy, and in all 10 cases with juvenile myoclonic epilepsy. Complete normalization of the EEG occurred in 13 of 20 patients with benign partial epilepy of childhood. Side-effects were minimal and caused discontinuation of treatment in only seven children. CONCLUSION:
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Authors | Bruria Ben-Zeev, Nathan Watemberg, Pinchas Lerman, Itshak Barash, Nathan Brand, Tally Lerman-Sagie |
Journal | Pediatrics international : official journal of the Japan Pediatric Society
(Pediatr Int)
Vol. 46
Issue 5
Pg. 521-4
(Oct 2004)
ISSN: 1328-8067 [Print] Australia |
PMID | 15491376
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Adolescent
- Australia
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Epilepsy
(drug therapy)
- Female
- Germany
- Humans
- Hyperventilation
(chemically induced)
- Ireland
- Israel
- Male
- Maximum Tolerated Dose
- Paresthesia
(chemically induced)
- Retrospective Studies
- Thiazines
(adverse effects, therapeutic use)
- Treatment Outcome
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