Acute neuropathy mimicking porphyria induced by aminolevulinic acid during photodynamic therapy.

An 82-year-old man developed severe, acute, predominantly motor polyneuropathy, signs of autonomic involvement, and skin changes following aminolevulinic acid (ALA) administration. The compound was used as a prodrug for photodynamic therapy of Barrett's esophagitis. Changes were observed in various parameters of the heme pathway. The case reported represents a rare response to ALA treatment, resembling an acute attack of hepatic porphyria with neurological features.
AuthorsConstantin Sylantiev, Nili Schoenfeld, Rivka Mamet, Galina B Groozman, Vivian E Drory
JournalMuscle & nerve (Muscle Nerve) Vol. 31 Issue 3 Pg. 390-3 (Mar 2005) ISSN: 0148-639X [Print] United States
PMID15490483 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Photosensitizing Agents
  • Aminolevulinic Acid
  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Aminolevulinic Acid (adverse effects)
  • Barrett Esophagus (drug therapy)
  • Diagnosis, Differential
  • Humans
  • Male
  • Nervous System Diseases (chemically induced, diagnosis)
  • Photochemotherapy (adverse effects)
  • Photosensitizing Agents (adverse effects)
  • Porphyrias (diagnosis)

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