Cytokine profile associated with human chronic schistosomiasis mansoni.

Abstract

This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.

• Authors: Andréa Magalhães, Delfin Gonzalez Miranda, Roberval Gonzalez Miranda, Maria Ilma Araújo, Adriana Almeida de Jesus, Angela Silva, Luciana B Santana, Edward Pearce, Edgar M Carvalho, Amélia Ribeiro de Jesus
• Journal: Memorias do Instituto Oswaldo Cruz (Mem Inst Oswaldo Cruz) Vol. 99 Issue 5 Suppl 1 Pg. 21-6 ( 2004) ISSN: 0074-0276 [Print] Brazil
• PMID: 15486630 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cytokines

Topics

• Adolescent
• Adult
• Animals
• Child
• Child, Preschool
• Chronic Disease
• Cytokines (blood, immunology)
• Disease Progression
• Female
• Humans
• Leukocytes, Mononuclear (metabolism)
• Liver Cirrhosis (diagnostic imaging, immunology, parasitology)
• Male
• Middle Aged
• Schistosoma mansoni (immunology)
• Schistosomiasis mansoni (blood, immunology)
• Severity of Illness Index
• Ultrasonography