Abstract | OBJECTIVE: DESIGN: Prospective, randomized controlled study. SETTING: Research laboratory in a university. SUBJECTS: Male Sprague-Dawley rats. INTERVENTIONS: After tracheostomy was performed under general anesthesia, lung injury was induced by intratracheal instillation of HCl. The PLV group was then subjected to conventional gas ventilation for 30 mins, followed by PLV using FC-77. The control group was subjected to conventional gas ventilation throughout the study period. MEASUREMENTS AND MAIN RESULTS: CONCLUSION: This study indicates that PLV using FC-77 suppresses the release of lipid mediators in our rat model of acute lung injury. However, further investigation is needed to clarify the precise mechanism of this effect.
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Authors | Yoh Hirayama, Hiroyuki Hirasawa, Shigeto Oda, Hidetoshi Shiga, Kenichi Matsuda, Hirokazu Ueno, Masataka Nakamura |
Journal | Critical care medicine
(Crit Care Med)
Vol. 32
Issue 10
Pg. 2085-9
(Oct 2004)
ISSN: 0090-3493 [Print] United States |
PMID | 15483418
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Arachidonic Acids
- Fluorocarbons
- Inflammation Mediators
- fluorocarbon 77
- Leukotriene B4
- Thromboxane A2
- 6-Ketoprostaglandin F1 alpha
- Hydrochloric Acid
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Topics |
- 6-Ketoprostaglandin F1 alpha
(biosynthesis)
- Animals
- Arachidonic Acids
(biosynthesis)
- Fluorocarbons
(pharmacology, therapeutic use)
- Hydrochloric Acid
(adverse effects)
- Inflammation Mediators
(metabolism)
- Leukotriene B4
(biosynthesis)
- Liquid Ventilation
(methods)
- Male
- Models, Animal
- Rats
- Rats, Sprague-Dawley
- Respiratory Distress Syndrome
(chemically induced, immunology, therapy)
- Thromboxane A2
(biosynthesis)
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