Abstract |
The acyclic nucleoside phosphonates [ HPMPC: cidofovir, Vistide; PMEA: adefovir dipivoxil, Hepsera; and PMPA: tenofovir, Viread] have proven to be effective in vitro (cell culture systems) and in vivo (animal models and clinical studies) against a wide variety of DNA virus and retrovirus infections, for example, cidofovir against herpesvirus [herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, human herpesvirus type 6, 7 and 8), polyoma-, papilloma-, adeno- and poxvirus (variola virus, cowpox virus, vaccinia virus, molluscum contagiosum virus and orf) infections; adefovir against herpesvirus, hepadnavirus [human hepatitis B virus] and retrovirus [HIV type-1 and 2, simian immunodeficiency virus and feline immunodeficiency virus] infections; and tenofovir against both hepadna- and retrovirus infections. Cidofovir has been officially approved for the treatment of cytomegalovirus retinitis in AIDS patients, tenofovir disoproxil fumarate ( Viread) for the treatment of HIV infections (i.e., AIDS) and adefovir dipivoxil for the treatment of chronic hepatitis B.
|
Authors | Eric De Clercq |
Journal | Expert review of anti-infective therapy
(Expert Rev Anti Infect Ther)
Vol. 1
Issue 1
Pg. 21-43
(Jun 2003)
ISSN: 1478-7210 [Print] England |
PMID | 15482100
(Publication Type: Journal Article, Review)
|
Chemical References |
- Antiviral Agents
- Organophosphonates
- Organophosphorus Compounds
- Cytosine
- Tenofovir
- Adenine
- Cidofovir
- adefovir dipivoxil
|
Topics |
- Adenine
(analogs & derivatives, therapeutic use)
- Animals
- Antiviral Agents
(therapeutic use)
- Cidofovir
- Cytosine
(analogs & derivatives, therapeutic use)
- DNA Virus Infections
(drug therapy)
- Disease Models, Animal
- Drug Resistance, Viral
- Humans
- Organophosphonates
- Organophosphorus Compounds
(therapeutic use)
- Retroviridae Infections
(drug therapy)
- Tenofovir
|