| Abstract | Injection of type 6b pneumococci into pigs results in a sharp rise in levels of interleukin-6 (IL-6) in blood, with an average peak value of 7,700 U/ml at 4 h and mortality in five of seven of these animals. Pretreatment at -24 h with the monocyte activator MTP-PE prevents this strong increase in IL-6 (peak value, 1,000 U/ml) and reduces mortality to zero of six animals. This suggests that MTP-PE, in addition to activating monocytes, protects animals by preventing the harmful increase of cytokines such as IL-6. |
| Authors | H W Ziegler-Heitbrock, B Passlick, E Käfferlein, P G Coulie, J R Izbicki
(Affiliation: Institute for Immunology, Munich, Germany.)
|
| Journal | Infection and immunity
(Infect Immun)
Vol. 60
Issue 4
Pg. 1692-4
(Apr 1992)
ISSN: 0019-9567 UNITED STATES |
| PMID | 1548092
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Adjuvants, Immunologic
- Interleukin-6
- Liposomes
- Phosphatidylethanolamines
- Acetylmuramyl-Alanyl-Isoglutamine
- muramylNAc-Ala-isoGln-Lys-tripeptide-PE
|
| Topics |
- Acetylmuramyl-Alanyl-Isoglutamine
(administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
- Adjuvants, Immunologic
(administration & dosage, pharmacology, therapeutic use)
- Animals
- Bacteremia
(prevention & control)
- Injections, Intravenous
- Interleukin-6
(biosynthesis, immunology)
- Liposomes
- Monocytes
(drug effects, metabolism)
- Phosphatidylethanolamines
(administration & dosage, pharmacology, therapeutic use)
- Pneumococcal Infections
(prevention & control)
- Swine
|
