Abstract | OBJECTIVE: DESIGN: Participants were recruited from outpatients of Osaka University Hospital. We investigated 386 hypertensive and 371 normotensive subjects. METHODS: Genotypes of TSC polymorphisms (G2736A, C1420T, G816C) were determined by the TaqMan polymerase chain reaction (PCR) method, and statistical significance was examined using JMP 5.0.1J (SAS Institute Inc., Cary, North Carolina, USA). The allele frequency of A2736 and T1420 was 6.0 and 3.0%, respectively, whereas we could not detect the G816C polymorphism in this study. Only the G2736A polymorphism was significantly associated with the prevalence of hypertension (P <0.04), and the estimated odds ratio was 1.8 (95% confidence interval, 1.1-3.0) in A2736 allele carriers. The odds ratio for hypertension in A2736 carriers was increased to 2.2 (1.1-4.9) in women (n=413), and further to 3.3 (1.4-8.0) in women with early onset of hypertension (< or = 50 years old). In addition, all subjects with the homozygous A2736 allele in this study (n=2) and the Swedish study (n=5) were hypertensive. CONCLUSION:
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Authors | Akiko Matsuo, Tomohiro Katsuya, Kazuhiko Ishikawa, Ken Sugimoto, Yoshio Iwashima, Koichi Yamamoto, Mitsuru Ohishi, Hiromi Rakugi, Toshio Ogihara |
Journal | Journal of hypertension
(J Hypertens)
Vol. 22
Issue 11
Pg. 2123-7
(Nov 2004)
ISSN: 0263-6352 [Print] England |
PMID | 15480096
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzothiadiazines
- Diuretics
- Receptors, Drug
- SLC12A3 protein, human
- Sodium Chloride Symporter Inhibitors
- Sodium Chloride Symporters
- Solute Carrier Family 12, Member 3
- Symporters
- thiazide receptor
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Topics |
- Age Distribution
- Aged
- Benzothiadiazines
- Diuretics
- Female
- Genetic Predisposition to Disease
(epidemiology)
- Genotype
- Humans
- Hypertension
(epidemiology, genetics)
- Japan
(epidemiology)
- Male
- Middle Aged
- Polymorphism, Genetic
- Receptors, Drug
(genetics)
- Risk Factors
- Sex Distribution
- Sodium Chloride Symporter Inhibitors
- Sodium Chloride Symporters
- Solute Carrier Family 12, Member 3
- Symporters
(genetics)
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