Anti-cyclic citrullinated antibodies: complementary to IgM rheumatoid factor in the early diagnosis of rheumatoid arthritis.

Abstract

AIMS:

To compare the diagnostic sensitivity of anti-cyclic citrullinated (CCP) antibodies and rheumatoid factor (RF) in rheumatoid arthritis (RA) within a general hospital setting.

METHOD:

Using the American College of Rheumatology (ACR) classification criteria as a gold standard, the frequency of RF and anti-CCP antibody positivity was compared between two groups of RA patients: those with disease duration less than 2 years (early RA, ERA) and those with disease duration more than 2 years (late RA, LRA).

RESULTS:

In ERA, the diagnostic sensitivity of RF and anti-CCP antibodies was 57% and 79% respectively. In LRA, it was 81% and 84% respectively.

CONCLUSION:

Anti-CCP antibodies are 20% more sensitivity than RF in the diagnosis of early RA.

• Authors: Kamal Solanki, Myfanwy Spellerberg, Peter Chapman, Peter Moller, John O'Donnell
• Journal: The New Zealand medical journal (N Z Med J) Vol. 117 Issue 1203 Pg. U1097 (Oct 08 2004) ISSN: 1175-8716 [Electronic] New Zealand
• PMID: 15477921 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Autoantibodies
• Biomarkers
• Immunoglobulin M
• Peptides, Cyclic
• Citrulline
• Rheumatoid Factor

Topics

• Arthritis, Rheumatoid (diagnosis, immunology)
• Autoantibodies (blood)
• Biomarkers (blood)
• Citrulline (immunology)
• Humans
• Immunoglobulin M (blood)
• Peptides, Cyclic (immunology)
• Rheumatoid Factor (blood)
• Sensitivity and Specificity