Primary myeloblastoma of the pineal region.

Abstract

The first case of a pinealis region tumor of the hematopoietic system without known leukemia (so-called primary myeloblastoma, primary granulocytic sarcoma) is reported. Two weeks after resection, the 3.5-year-old patient suffered from a local recurrence. At this time, a bone marrow infiltration by leukemic blasts was diagnosed for the first time. An aggressive chemotherapy and radiation induced a complete remission, over a 26-month follow-up period. We examined the removed tumor tissue by routine histology methods, immuno- and enzyme histochemistry and electron microscopy. The CSF was studied by conventional microscopy and enzyme cytochemistry. We discuss the epidemiological data of nine previously published cases of primary intracranial myeloblastoma.

• Authors: R Voessing, F Berthold, K E Richard, F Thun, R Schroeder, G R Krueger
• Journal: Clinical neuropathology (Clin Neuropathol) 1992 Jan-Feb Vol. 11 Issue 1 Pg. 11-5 ISSN: 0722-5091 [Print] Germany
• PMID: 1547578 (Publication Type: Case Reports, Journal Article)

Topics

• Brain Neoplasms (pathology, surgery)
• Chemotherapy, Adjuvant
• Child, Preschool
• Combined Modality Therapy
• Cranial Irradiation
• Follow-Up Studies
• Humans
• Leukemia, Myeloid (pathology, surgery)
• Male
• Microscopy, Electron
• Neoplasm Recurrence, Local (pathology, surgery)
• Pineal Gland (pathology, surgery)