Abstract | OBJECTIVES: METHODS: RESULTS:
Drug dose was associated with clinical response when we analyzed adjusted doses based on molecular drug weight (P = 0.002). 6-Thioguanine levels also were associated with clinical response (P = 0.003) and the maximal difference between responders and non-responders was seen at 6-thioguanine levels greater than 260 pmol/8 x 10(8) RBC. Relative leukopenia, defined as white blood cell count less than either 5.0 or 4.0 K/uL, was not associated with clinical response (P = 0.13 and 0.77 respectively). CONCLUSIONS:
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Authors | Jean-Paul Achkar, Tyler Stevens, Kirk Easley, Aaron Brzezinski, Douglas Seidner, Bret Lashner |
Journal | Inflammatory bowel diseases
(Inflamm Bowel Dis)
Vol. 10
Issue 4
Pg. 339-45
(Jul 2004)
ISSN: 1078-0998 [Print] England |
PMID | 15475740
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antirheumatic Agents
- Immunosuppressive Agents
- Mercaptopurine
- Azathioprine
|
Topics |
- Adult
- Antirheumatic Agents
- Azathioprine
(administration & dosage, pharmacology, therapeutic use)
- Dose-Response Relationship, Drug
- Endpoint Determination
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage, pharmacology, therapeutic use)
- Inflammatory Bowel Diseases
(drug therapy, pathology)
- Leukopenia
(chemically induced)
- Male
- Mercaptopurine
(administration & dosage, pharmacology, therapeutic use)
- Middle Aged
- Treatment Outcome
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