Abstract | UNLABELLED: This study assessed the radiation dosimetry of 99mTc-labeled ethylene dicysteine (EC) C225 (EC-C225), a promising radioligand for functional tumor imaging. METHODS: Whole-body scanning was performed on 6 patients with head and neck squamous cell carcinoma up to 24 h after administration of 99mTc-EC-C225. Alternate patients who had been randomized to receive C225 in a phase III trial received 99mTc-EC-C225 before their 20-mg test dose or after their 400 mg/m2 loading dose of unlabeled C225 (patients 1/3/5 and 2/4/6, respectively). Radiation dosimetry was assessed using the MIRD method. RESULTS: The critical organ was the kidney, with an average radiation-absorbed dose for all 6 patients of 0.0274 mGy/MBq. The average total-body absorbed dose was 0.0022 mGy/MBq (0.243 cGy/1,110 MBq). CONCLUSION: The new radiopharmaceutical 99mTc-EC-C225 appears to have reasonable dosimetric properties for a diagnostic nuclear medicine agent. Correlation of the imaging results with clinical findings is the next step.
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Authors | Naomi R Schechter, Richard E Wendt 3rd, David J Yang, Ali Azhdarinia, William D Erwin, Anne M Stachowiak, Lyle D Broemeling, E Edmund Kim, James D Cox, Donald A Podoloff, K Kian Ang |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 45
Issue 10
Pg. 1683-7
(Oct 2004)
ISSN: 0161-5505 [Print] United States |
PMID | 15471833
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Validation Study)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Radiopharmaceuticals
- Technetium
- Cetuximab
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Topics |
- Antibodies, Monoclonal
(pharmacokinetics, therapeutic use)
- Antibodies, Monoclonal, Humanized
- Body Burden
- Carcinoma, Squamous Cell
(diagnostic imaging, metabolism, radiotherapy)
- Cetuximab
- Head and Neck Neoplasms
(diagnostic imaging, metabolism, radiotherapy)
- Humans
- Organ Specificity
- Positron-Emission Tomography
(methods)
- Radiation Dosage
- Radiometry
(methods)
- Radiopharmaceuticals
(pharmacokinetics)
- Sensitivity and Specificity
- Technetium
(pharmacokinetics, therapeutic use)
- Tissue Distribution
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