Radiation dosimetry of 99mTc-labeled C225 in patients with squamous cell carcinoma of the head and neck.

Abstract

UNLABELLED:

This study assessed the radiation dosimetry of 99mTc-labeled ethylene dicysteine (EC) C225 (EC-C225), a promising radioligand for functional tumor imaging.

METHODS:

Whole-body scanning was performed on 6 patients with head and neck squamous cell carcinoma up to 24 h after administration of 99mTc-EC-C225. Alternate patients who had been randomized to receive C225 in a phase III trial received 99mTc-EC-C225 before their 20-mg test dose or after their 400 mg/m2 loading dose of unlabeled C225 (patients 1/3/5 and 2/4/6, respectively). Radiation dosimetry was assessed using the MIRD method.

RESULTS:

The critical organ was the kidney, with an average radiation-absorbed dose for all 6 patients of 0.0274 mGy/MBq. The average total-body absorbed dose was 0.0022 mGy/MBq (0.243 cGy/1,110 MBq).

CONCLUSION:

The new radiopharmaceutical 99mTc-EC-C225 appears to have reasonable dosimetric properties for a diagnostic nuclear medicine agent. Correlation of the imaging results with clinical findings is the next step.

• Authors: Naomi R Schechter, Richard E Wendt 3rd, David J Yang, Ali Azhdarinia, William D Erwin, Anne M Stachowiak, Lyle D Broemeling, E Edmund Kim, James D Cox, Donald A Podoloff, K Kian Ang
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 45 Issue 10 Pg. 1683-7 (Oct 2004) ISSN: 0161-5505 [Print] United States
• PMID: 15471833 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Validation Study)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Radiopharmaceuticals
• Technetium
• Cetuximab

Topics

• Antibodies, Monoclonal (pharmacokinetics, therapeutic use)
• Antibodies, Monoclonal, Humanized
• Body Burden
• Carcinoma, Squamous Cell (diagnostic imaging, metabolism, radiotherapy)
• Cetuximab
• Head and Neck Neoplasms (diagnostic imaging, metabolism, radiotherapy)
• Humans
• Organ Specificity
• Positron-Emission Tomography (methods)
• Radiation Dosage
• Radiometry (methods)
• Radiopharmaceuticals (pharmacokinetics)
• Sensitivity and Specificity
• Technetium (pharmacokinetics, therapeutic use)
• Tissue Distribution