Abstract |
Chronotoxicologic profiles of nedaplatin, a platinum compound, were evaluated in rats maintained under a 12 light/12 dark cycle with light from 07:00h to 19:00 h. Nedaplatin (5 mg/kg) was injected intravenously, once a week for 5 weeks at 08:00h or 20:00h. The suppression of body weight gain and reduction of creatinine clearance were significantly greater with the 20:00h than 08:00h treatment. Accumulation of nedaplatin in the renal cortex and bone marrow were also greater with 20:00 h treatment. There were significant relationships between the nedaplatin content in the kidney and bone marrow and degree of injury to each. These results suggest that the nedaplatin-induced toxicity depends on its dosing-time, and it is greater with treatment at 20:00 h, during the active phase. The dosing-time dependency in the accumulation of nedaplatin in the tissue of the organs might be involved in this chronotoxicologic phenomenon.
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Authors | Yimin Cui, Koh-Ichi Sugimoto, Yoshiko Kawai, Toshiaki Sudoh, Munekazu Gemba, Akio Fujimura |
Journal | Chronobiology international
(Chronobiol Int)
Vol. 21
Issue 4-5
Pg. 601-11
(Jul 2004)
ISSN: 0742-0528 [Print] England |
PMID | 15470957
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Organoplatinum Compounds
- nedaplatin
- Creatinine
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, pharmacokinetics, toxicity)
- Bone Marrow
(drug effects, metabolism)
- Chronotherapy
- Circadian Rhythm
(physiology)
- Creatinine
(metabolism)
- Kidney Cortex
(drug effects, metabolism)
- Leukocyte Count
- Male
- Organoplatinum Compounds
(administration & dosage, pharmacokinetics, toxicity)
- Photoperiod
- Rats
- Rats, Sprague-Dawley
- Weight Gain
(drug effects)
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