Abstract | OBJECTIVE: BACKGROUND: CASE: A 9-year-old girl presented with cognitive impairments secondary to shaken-baby syndrome at 3 weeks of age. She was receiving many medications, including dextroamphetamine, methylphenidate, and clonidine, that were not effective in improving her cognitive status or decreasing her hypersexuality. She was weaned from stimulants and clonidine and prescribed amantadine 100 mg bid with improvement of attention, concentration, and cognition, although hypersexuality remained. She was then started on propranolol 10 mg tid and a gradual increase to 40 mg tid with amelioration of hypersexuality and hyperactivity and no unwanted effects noted. Self-weaning of propranolol was associated with the return of hypersexuality. The combination of amantadine and propranolol led to improvement of cognition and behavior, especially intellectual functioning and appropriate socialization with peers, respectively. CONCLUSION:
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Authors | J G Schmidt, W N Schneider |
Journal | Neurorehabilitation and neural repair
(Neurorehabil Neural Repair)
Vol. 14
Issue 2
Pg. 155-8
( 2000)
ISSN: 1545-9683 [Print] United States |
PMID | 15470827
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Dopamine Agents
- Propranolol
- Amantadine
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Amantadine
(therapeutic use)
- Child
- Child Behavior Disorders
(drug therapy, etiology)
- Cognition Disorders
(drug therapy, etiology)
- Dopamine Agents
(therapeutic use)
- Female
- Humans
- Propranolol
(therapeutic use)
- Sexual Behavior
(drug effects)
- Shaken Baby Syndrome
(psychology)
- Treatment Outcome
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