Abstract | BACKGROUND: METHODS: RESULTS: In part A, fluconazole decreased the area under the plasma concentration-time curve (AUC), percent of dose excreted in 24-hour urine, and formation clearance (CL f ) of the hydroxylamine by 37%, 53%, and 61%, respectively (paired t test, P < .05). Rifabutin increased the AUC, percent excreted, and CL f of the hydroxylamine by 55%, 45%, and 53%, respectively ( P < .05). Fluconazole plus rifabutin decreased the AUC, percent excreted, and CL f of the hydroxylamine by 21%, 37%, and 46%, respectively ( P < .05). In part B the fluconazole data were similar to those of part A. Overall, clarithromycin had no effect on hydroxylamine production. CONCLUSIONS:
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Authors | Helen R Winter, Carol B Trapnell, John T Slattery, Mark Jacobson, Debra L Greenspan, Thomas M Hooton, Jashvant D Unadkat |
Journal | Clinical pharmacology and therapeutics
(Clin Pharmacol Ther)
Vol. 76
Issue 4
Pg. 313-22
(Oct 2004)
ISSN: 0009-9236 [Print] United States |
PMID | 15470330
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Infective Agents
- sulfamethoxazole hydroxylamine
- Rifabutin
- Trimethoprim, Sulfamethoxazole Drug Combination
- Fluconazole
- Clarithromycin
- Sulfamethoxazole
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Topics |
- Adult
- Anti-Infective Agents
(pharmacology)
- Area Under Curve
- CD4 Lymphocyte Count
- Clarithromycin
(pharmacology)
- Drug Interactions
- Female
- Fluconazole
(pharmacology)
- HIV Infections
- HIV-1
- Humans
- Male
- Middle Aged
- Rifabutin
(pharmacology)
- Sulfamethoxazole
(analogs & derivatives, blood)
- Trimethoprim, Sulfamethoxazole Drug Combination
(adverse effects, metabolism, pharmacokinetics)
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