JAGGED1 expression is associated with prostate cancer metastasis and recurrence.

Abstract	Recent studies suggest that NOTCH signaling can promote epithelial-mesenchymal transitions and augment signaling through AKT, an important growth and survival pathway in epithelial cells and prostate cancer in particular. Here we show that JAGGED1, a NOTCH receptor ligand, is significantly more highly expressed in metastatic prostate cancer as compared with localized prostate cancer or benign prostatic tissues, based on immunohistochemical analysis of JAGGED1 expression in human tumor samples from 154 men. Furthermore, high JAGGED1 expression in a subset of clinically localized tumors was significantly associated with recurrence, independent of other clinical parameters. These findings support a model in which dysregulation of JAGGED1 protein levels plays a role in prostate cancer progression and metastasis and suggest that JAGGED1 may be a useful marker in distinguishing indolent and aggressive prostate cancers.
Authors	Sandro Santagata, Francesca Demichelis, Alberto Riva, Sooryanarayana Varambally, Matthias D Hofer, Jeffery L Kutok, Robert Kim, Jeffery Tang, James E Montie, Arul M Chinnaiyan, Mark A Rubin, Jon C Aster
Journal	Cancer research (Cancer Res) Vol. 64 Issue 19 Pg. 6854-7 (Oct 01 2004) ISSN: 0008-5472 [Print] United States
PMID	15466172 (Publication Type: Journal Article)
Chemical References	Antibodies Calcium-Binding Proteins Intercellular Signaling Peptides and Proteins JAG1 protein, human Jagged-1 Protein Membrane Proteins Proteins Serrate-Jagged Proteins
Topics	Adult Aged Aged, 80 and over Antibodies (immunology) Antibody Specificity Calcium-Binding Proteins Cell Line, Tumor Disease Progression Humans Immunohistochemistry Intercellular Signaling Peptides and Proteins Jagged-1 Protein Male Membrane Proteins Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local (metabolism, pathology) Prostatectomy Prostatic Intraepithelial Neoplasia (metabolism, pathology) Prostatic Neoplasms (metabolism, pathology, surgery) Protein Biosynthesis Proteins (immunology) Serrate-Jagged Proteins

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