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Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats.

Abstract
The new orally active drug laquinimod (ABR-215062) was evaluated in experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. EAE shares important immunological and clinical features with multiple sclerosis (MS). Doses of 16, 1.6 and 0.16 mg/kg/day laquinimod dose-dependently inhibited disease and showed better disease inhibitory effects as compared to roquinimex (Linomide). Furthermore, laquinimod inhibited the inflammation of both CD4+ T cells and macrophages into central nervous tissues, i.e. the spinal cord. It also changed the cytokine balance in favour of TH2/TH3 cytokines IL-4, IL-10 and TGF-beta. Laquinimod therefore represents a new orally active immunoregulatory drug without general immunosuppressive properties with a potential for the treatment of severe autoimmune diseases like MS.
AuthorsJian-She Yang, Ling-Yun Xu, Bao-Guo Xiao, Gunnar Hedlund, Hans Link
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 156 Issue 1-2 Pg. 3-9 (Nov 2004) ISSN: 0165-5728 [Print] Netherlands
PMID15465591 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Cytokines
  • Hydroxyquinolines
  • Quinolones
  • Transforming Growth Factor beta
  • laquinimod
Topics
  • Animals
  • Cytokines (biosynthesis)
  • Encephalomyelitis, Autoimmune, Experimental (blood, immunology, prevention & control)
  • Female
  • Hydroxyquinolines (pharmacology, therapeutic use)
  • Quinolones
  • Rats
  • Rats, Inbred Lew
  • Th1 Cells (drug effects, immunology, metabolism)
  • Th2 Cells (drug effects, immunology, metabolism)
  • Transforming Growth Factor beta (biosynthesis, immunology)

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