Isolated cranial neuropathy associated with anti-glycolipid antibodies.

Abstract

We describe seven patients with isolated cranial neuropathy in whom serum anti-glycolipid antibodies were detected. Trigeminal sensory neuropathy was found in four patients, who had exhibited symptoms for 2 months to 4 years. The other three patients showed facial nerve palsy with or without ophthalmoparesis. Temporal profile analysis of anti-glycolipid antibodies revealed that titers of anti-glycolipid IgM antibodies against GM2 and LM1 gradually decreased in patients having chronic trigeminal sensory neuropathy. In patients with acute trigeminal sensory neuropathy, elevation of anti-LM1 antibody titers continued over 12 months although anti-GalNAc-GD1a antibody disappeared. On the other hand, titers of anti-glycolipid antibodies rapidly decreased in patients with acute facial nerve palsy with or without ophthalmoparesis. We conclude that anti-glycolipid antibodies may play an important role in the development of isolated cranial neuropathy in some patients.

• Authors: Makoto Kunishige, Takao Mitsui, Hiide Yoshino, Atsuko Asano, Miho Tsuruo, Itsuro Endo, Fumikazu Yagi, Toshio Matsumoto
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 225 Issue 1-2 Pg. 51-5 (Oct 15 2004) ISSN: 0022-510X [Print] Netherlands
• PMID: 15465085 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Anti-Idiotypic
• Gangliosides
• Glycolipids
• LM1 ganglioside
• anti-IgM
• G(M2) Ganglioside
• IV(4)-galactosyl-N-acetylganglioside GD1a

Topics

• Action Potentials (physiology, radiation effects)
• Adult
• Aged
• Antibodies, Anti-Idiotypic (blood)
• Blinking (physiology)
• Cranial Nerve Diseases (classification, immunology, physiopathology, virology)
• Cytomegalovirus (immunology)
• Electric Stimulation (methods)
• Female
• G(M2) Ganglioside (immunology)
• Gangliosides (immunology)
• Glycolipids (immunology)
• Herpesvirus 4, Human (immunology)
• Humans
• Immunoenzyme Techniques (methods)
• Male
• Middle Aged
• Neural Conduction (physiology)
• Time Factors