| Abstract | Collagen vascular diseases and malignancies have common systemic and immune features. We report a case of a 21 year old female patient with constitutional symptoms, polyserositis, spontaneous rupture of the spleen, leukocytoclastic vasculitis and acute renal failure. The tentative diagnosis of SLE was made because she developed a positive antinuclear factor (1/640), with anti-SSA antibodies and a positive lupus anticoagulans. Two months later a cervical lymphadenopathy occurred while recieving treatment with prednisolone. A lymph node biopsy revealed morphologic features of a SLE, similar to those observed in multicentric Castleman's disease (MCD). MCD is a distinct type of a lymphoproliferative disorder of unknown etiology. The difficulties in differential diagnosis of these two diseases are discussed. |
| Authors | K Van de Voorde, H De Raeve, C E De Block, N Van Regenmortel, J F Van Offel, L S De Clerck, W J Stevens
(Affiliation: Department of Immunology/Allergology/Reumatology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium. Immuno at ua.ac.be)
|
| Journal | Acta clinica Belgica
(Acta Clin Belg)
2004 May-Jun
Vol. 59
Issue 3
Pg. 161-4
ISSN: 0001-5512 Belgium |
| PMID | 15462513
(Publication Type: Case Reports, Journal Article)
|
| Topics |
- Adult
- Biopsy
- Diagnosis, Differential
- Fatal Outcome
- Female
- Giant Lymph Node Hyperplasia
(complications, diagnosis, pathology)
- Humans
- Lupus Erythematosus, Systemic
(complications, diagnosis, pathology)
- Lymph Nodes
(pathology)
- Serositis
(etiology)
|
