Abstract | BACKGROUND: Low-dose dobutamine stress echocardiography (LDDE) has become a useful and safe method for identifying hibernating or stunned myocardium and for predicting improvement in wall motion after coronary revascularization. METHODS AND RESULTS: In the present study, fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET), rest-redistribution thallium-201 ((201)Tl) single-photon emission computed tomography (RR-Tl SPECT), (123)I-15-(p-iodophenyl)-3-(R,S)-methyl pentadecanoic acid ( BMIPP) and LDDE were performed in 30 patients with acute myocardial infarction (AMI) at 10+/-3 days after the onset of AMI. Also, exercise (201)Tl reinjection SPECT (RI-Tl SPECT) was performed at 14+/-2 days. Follow-up echocardiography was performed 5+/-3 months later in all patients after interventional therapy for the assessment of functional recovery. Of the 390 segments analyzed by echocardiography, 110 (28%) had abnormal wall motion. There were no significant differences between RR-Tl SPECT and LDDE in sensitivity, specificity, positive predictive value and negative predictive value using the chi(2)-test; however, in akinetic segments, there was a significant difference in sensitivity. Among FDG-PET, RI-Tl SPECT, BMIPP and LDDE, there were significant differences in 3 variables. In akinetic segments, LDDE is superior to RR-Tl SPECT in sensitivity and to FDG-PET in specificity. In hypokinetic segments, LDDE is superior to RI-Tl SPECT and BMIPP in sensitivity, and to FDG-PET and BMIPP in specificity. CONCLUSIONS: LDDE could detect functional recovery of viable myocardium in the early period of AMI and can be performed easily and safely.
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Authors | Tomoko Tani, Masakazu Teragaki, Hiroyuki Watanabe, Takashi Muro, Hiroyuki Yamagishi, Kaname Akioka, Minoru Yoshiyama, Kazuhide Takeuchi, Junichi Yoshikawa |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 68
Issue 10
Pg. 950-7
(Oct 2004)
ISSN: 1346-9843 [Print] Japan |
PMID | 15459470
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Cardiotonic Agents
- Thallium Radioisotopes
- Dobutamine
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Topics |
- Aged
- Cardiotonic Agents
(administration & dosage)
- Dobutamine
(administration & dosage)
- Echocardiography, Stress
(methods)
- Female
- Humans
- Male
- Middle Aged
- Myocardial Stunning
(diagnosis)
- Positron-Emission Tomography
(methods)
- Thallium Radioisotopes
- Tomography, Emission-Computed, Single-Photon
(methods)
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