Abstract | OBJECTIVE: METHODS:
Recurrent miscarriage cases (n = 135) included women who had a subsequent miscarriage in which an abortus karyotype was obtained. Controls (n = 150) were patients experiencing a sporadic miscarriage who had fetal karyotypes performed as part of a study to assess the utility of abortus tissue for transplantation. Karyotype analysis was performed using standard G-banding techniques. RESULTS: Abortuses from 122 cases and 133 controls were successfully karyotyped. Thirty-one (25.4%) abortuses from cases and 56 (42.1%) from controls were aneuploid (odds ratio 0.47, 95% confidence interval 0.27-0.80). Aneuploid abortuses occurred in 20% of cases and 25% of controls, aged 20-29 years, 19% of cases and 24% of controls, aged 30-34 years, 35% of cases and 47% of controls, aged 35-39 years, and 50% of both cases and controls, aged 40 years or older (not significant). Of 30 cases in whom 2 or more miscarriages were karyotyped, 3 (10%) had aneuploidy in each abortus. CONCLUSION: LEVEL OF EVIDENCE: II-2
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Authors | Amy E Sullivan, Robert M Silver, D Yvette LaCoursiere, T Flint Porter, D Ware Branch |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 104
Issue 4
Pg. 784-8
(Oct 2004)
ISSN: 0029-7844 [Print] United States |
PMID | 15458902
(Publication Type: Journal Article)
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Topics |
- Abortion, Habitual
(epidemiology, genetics)
- Adolescent
- Adult
- Aneuploidy
- Case-Control Studies
- Female
- Humans
- Karyotyping
- Medical Records
- Middle Aged
- Pregnancy
- Retrospective Studies
- Utah
(epidemiology)
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