Abstract | BACKGROUND: METHODS: RESULTS: The HFS group exhibited hypertension, hyperlipidemia, insulin resistance, obesity, significant down-regulation of hepatic cholesterol 7alpha-hydroxylase (the rate-limiting step in cholesterol catabolism) and low-density lipoprotein ( LDL) receptor ( LDL-R, the primary pathway of LDL clearance). In contrast, hepatic tissue acyl-coenzyme A: cholesterol acyltransferase (ACAT-2, the primary enzyme involved in intracellular esterification of cholesterol) and scavenger-receptor class B, type 1 (SR-B1 or HDL receptor) were up-regulated. While 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA) reductase mRNA expression was increased, its protein abundance and activity were unchanged, and HMG-CoA reductase-to- cholesterol 7alpha-hydroxylase ratio was increased in HFS-fed animals. CONCLUSION:
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Authors | Christian K Roberts, Kaihui Liang, R James Barnard, Choong H Kim, Nosratola D Vaziri |
Journal | Kidney international
(Kidney Int)
Vol. 66
Issue 4
Pg. 1503-11
(Oct 2004)
ISSN: 0085-2538 [Print] United States |
PMID | 15458444
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Dietary Sucrose
- Receptors, Immunologic
- Receptors, LDL
- Receptors, Scavenger
- Scarb1 protein, rat
- Scavenger Receptors, Class B
- Hydroxymethylglutaryl CoA Reductases
- Cholesterol 7-alpha-Hydroxylase
- Sterol O-Acyltransferase
- sterol O-acyltransferase 2
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Topics |
- Animal Feed
- Animals
- Cholesterol 7-alpha-Hydroxylase
(metabolism)
- Dietary Sucrose
(pharmacology)
- Female
- Hydroxymethylglutaryl CoA Reductases
(metabolism)
- Hyperlipidemias
(metabolism)
- Liver
(enzymology)
- Metabolic Syndrome
(metabolism)
- Obesity
(metabolism)
- Rats
- Rats, Inbred F344
- Receptors, Immunologic
(metabolism)
- Receptors, LDL
(metabolism)
- Receptors, Scavenger
- Scavenger Receptors, Class B
- Sterol O-Acyltransferase
(metabolism)
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