Role of ciprofloxacin in typhoid fever.

Abstract

A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol. Eighty patients between 20-45 years with positive blood culture were included in the study. Seventy five percent patients treated with ciprofloxacin became afebrile within 72 hours while with chloramphenicol it took upto 120-144 hours for the same percentage of patients to become afebrile. Four patients resistant to chloramphenicol, cotrimoxazole and ampicillin/amoxycillin, also responded to ciprofloxacin. There were no significant adverse effects indicating that ciprofloxacin is safe and effective drug for resistant and nonresistant cases of typhoid fever.

• Authors: M A Akhtar, A Hussain, K A Karamat, N Naqi, N Zubdi
• Journal: JPMA. The Journal of the Pakistan Medical Association (J Pak Med Assoc) Vol. 42 Issue 1 Pg. 9-10 (Jan 1992) ISSN: 0030-9982 [Print] Pakistan
• PMID: 1545485 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Ciprofloxacin
• Chloramphenicol

Topics

• Adult
• Chloramphenicol (therapeutic use)
• Ciprofloxacin (therapeutic use)
• Humans
• Middle Aged
• Typhoid Fever (drug therapy)