Modulatory effect of gentisic acid on the augmentation of biochemical events of tumor promotion stage by benzoyl peroxide and ultraviolet radiation in Swiss albino mice.

Abstract	The present study was carried out to study the effect of gentisic acid (2,5-dihydroxybenzoic acid (2,5-DHBA)) on the tumor promotion related events of carcinogenesis in murine skin. Benzoyl peroxide (BPO) (20 mg/0.2 ml/animal) and ultraviolet radiations (UVR) (0.420 J/m2/s) were used to induce tumor promotion response and oxidative stress and caused significant depletion in the detoxification and antioxidant enzyme armory with concomitant elevation in malondialdehyde (MDA) formation, hydrogen peroxide (H2O2) generation, ornithine decarboxylase (ODC) activity and unscheduled DNA synthesis. However, gentisic acid pretreatment at two different doses restored the levels of the above said parameters (P < 0.05) in a dose-dependent manner except in the case of ODC activity. Therefore, we propose that it might suppress the promotion stage via inhibition of oxidative stress but may not affect the polyamine biosynthetic pathway.
Authors	Sonia Sharma, Naghma Khan, Sarwat Sultana
Journal	Toxicology letters (Toxicol Lett) Vol. 153 Issue 3 Pg. 293-302 (Nov 28 2004) ISSN: 0378-4274 [Print] Netherlands
PMID	15454305 (Publication Type: Journal Article)
Chemical References	Gentisates Keratolytic Agents Proteins DNA Hydrogen Peroxide Glucosephosphate Dehydrogenase Catalase Glutathione Peroxidase NAD(P)H Dehydrogenase (Quinone) Glutathione Reductase Glutathione Transferase Ornithine Decarboxylase Glutathione 2,5-dihydroxybenzoic acid Benzoyl Peroxide
Topics	Animals Benzoyl Peroxide (antagonists & inhibitors, toxicity) Catalase (metabolism) DNA (biosynthesis, genetics) Female Gentisates (pharmacology) Glucosephosphate Dehydrogenase (metabolism) Glutathione (metabolism) Glutathione Peroxidase (metabolism) Glutathione Reductase (metabolism) Glutathione Transferase (metabolism) Hydrogen Peroxide (metabolism) Keratolytic Agents (toxicity) Lipid Peroxidation (drug effects, radiation effects) Mice NAD(P)H Dehydrogenase (Quinone) (metabolism) Neoplasms, Radiation-Induced (pathology, prevention & control) Ornithine Decarboxylase (metabolism) Proteins (metabolism) Skin Neoplasms (etiology, pathology, prevention & control) Ultraviolet Rays

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