Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS: These findings suggest that antibodies are important mediators of atheroprotective immune responses directed to oxidized LDL. Thus, passive immunization against MDA-modified apoB-100 peptide sequences may represent a novel therapeutic approach for prevention and treatment of cardiovascular disease.
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Authors | Alexandru Schiopu, Jenny Bengtsson, Ingrid Söderberg, Sabina Janciauskiene, Stefan Lindgren, Mikko P S Ares, Prediman K Shah, Roland Carlsson, Jan Nilsson, Gunilla Nordin Fredrikson |
Journal | Circulation
(Circulation)
Vol. 110
Issue 14
Pg. 2047-52
(Oct 05 2004)
ISSN: 1524-4539 [Electronic] United States |
PMID | 15451805
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoprotein B-100
- Apolipoproteins B
- Apolipoproteins E
- Immunoglobulin Fragments
- Immunoglobulin G
- Immunoglobulin Variable Region
- Immunoglobulin lambda-Chains
- Lipoproteins, LDL
- Peptide Fragments
- Recombinant Fusion Proteins
- oxidized low density lipoprotein
- Malondialdehyde
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Topics |
- Amino Acid Sequence
- Animals
- Apolipoprotein B-100
- Apolipoproteins B
(chemistry, immunology)
- Apolipoproteins E
(deficiency, genetics)
- Arteriosclerosis
(pathology, prevention & control)
- Drug Evaluation, Preclinical
- Humans
- Immunization, Passive
- Immunoglobulin Fragments
(genetics, immunology, therapeutic use)
- Immunoglobulin G
(genetics, immunology, therapeutic use)
- Immunoglobulin Variable Region
(genetics, immunology, therapeutic use)
- Immunoglobulin lambda-Chains
(genetics)
- Lipoproteins, LDL
(metabolism, pharmacology)
- Macrophages
(pathology)
- Male
- Malondialdehyde
(chemistry, immunology)
- Mice
- Mice, Knockout
- Molecular Sequence Data
- Monocytes
(metabolism)
- Peptide Fragments
(chemistry, immunology)
- Recombinant Fusion Proteins
(immunology, therapeutic use)
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