Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer.

Abstract

PURPOSE:

Deficiency of the mannan-binding lectin (MBL) pathway of innate immunity is associated with increased susceptibility to infections. In patients with colorectal cancer (CRC), postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate (1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for CRC, and (2) the role of MBL in acute phase response compared to C-reactive protein (CRP).

METHODS:

Preoperative MBL concentration, MBL-associated serine protease (MBL/MASP) activity and CRP were determined in serum from 611 patients and 150 healthy controls. The patients were observed for 8 years. Postoperative infections, recurrence and survival were recorded.

RESULTS:

The MBL pathway components were increased in the patients compared with the healthy controls (p < 0.0001). Low MBL levels were predictive of pneumonia (p = 0.01), and pneumonia (n = 87) was associated with poor survival (p = 0.003; HR = 1.5; 95% CI, 1.1 to 1.9). MBL and MBL/MASP activity showed no correlation with CRP (Spearman's rho = 0.02; 95% CI, -0.06 to 0.10).

CONCLUSION:

Low preoperative MBL levels are predictive of pneumonia, which is associated with poorer survival. MBL concentration and MBL/MASP activity was not predictive of other postoperative infections or long-term prognosis, and showed no correlation with CRP.

• Authors: Henriette Ytting, Ib Jarle Christensen, Jens Christian Jensenius, Steffen Thiel, Hans Jørgen Nielsen
• Journal: Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother) Vol. 54 Issue 3 Pg. 265-72 (Mar 2005) ISSN: 0340-7004 [Print] Germany
• PMID: 15449036 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Mannose-Binding Lectin
• C-Reactive Protein
• Mannose-Binding Protein-Associated Serine Proteases
• Serine Endopeptidases

Topics

• Acute-Phase Reaction
• C-Reactive Protein (metabolism)
• Colorectal Neoplasms (metabolism, mortality, surgery)
• Female
• Humans
• Male
• Mannose-Binding Lectin (chemistry, physiology)
• Mannose-Binding Protein-Associated Serine Proteases
• Prognosis
• Proportional Hazards Models
• Serine Endopeptidases (blood)
• Time Factors
• Treatment Outcome