[A resected case of thoracic esophageal cancer in which pCR was obtained using low-dose of nedaplatin (CDGP)/5-FU and radiotherapy].

Abstract

This is a report of a case with esophageal cancer in which pathological CR was obtained by neoadjvant chemoradiotherapy using a low-dose of nedaplatin (CDGP)/5-FU. The patient was a male aged 76. A protuberant lesion diagnosed as esophageal cancer was found in the middle thoracic esophagus by esophagography. Since another lesion in the upper thoracic esophagus was revealed by endoscopy, metastasis to the cervical lymph nodes was diagnosed by ultrasonography, and preoperative chemoradiotherapy combining a low dose of CDGP/5-FU with radiotherapy was performed. As side effects of this treatment, grade 2 stomatitis and granulocytopenia were observed. The main lesion of the esophagus was found to have significantly diminished through endoscopy after completion of the treatment, and with no malignant cells obtained by biopsy. No cervical lymph nodes were found. It was diagnosed as partial response (PR) through imaging diagnosis. Radical resection of esophageal cancer under right thoracotomy and laparotomy was performed. Operative findings were Ch x R-T3N0M0 Stage II R0 D2 Cur A. Pathological examination of resected specimens revealed no viable cancer cells in the esophagus or metastasis to the dissected lymph nodes. Neoadjuvant chemoradiotherapy using a low-dose of CDGP/5-FU is an effective treatment for esophageal cancer.

• Authors: Masashi Takemura, Harushi Osugi, Shigeru Lee, Masahiro Kaneko, Yoshinori Tanaka, Yushi Fujiwara, Satoshi Nishizawa, Hiroshi Iwasaki, Masayuki Higashino
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 31 Issue 9 Pg. 1399-402 (Sep 2004) ISSN: 0385-0684 [Print] Japan
• PMID: 15446565 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Organoplatinum Compounds
• nedaplatin
• Fluorouracil

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, radiotherapy, surgery)
• Combined Modality Therapy
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Esophageal Neoplasms (drug therapy, radiotherapy, surgery)
• Esophagectomy
• Fluorouracil (administration & dosage)
• Humans
• Male
• Organoplatinum Compounds (administration & dosage)
• Remission Induction