Disease associations and pathogenic role of antineutrophil cytoplasmic autoantibodies in vasculitis.

Abstract

Antineutrophil cytoplasmic autoantibodies are a useful diagnostic serologic marker for a variety of well-known vasculitic syndromes, including Wegener's granulomatosis, polyarteritis nodosa (especially microscopic polyarteritis nodosa), Churg-Strauss syndrome, and pulmonary-renal syndrome with alveolar capillaritis. Although most patients with antineutrophil cytoplasmic autoantibody-associated disease have systemic disease, disease limited to one organ does occur, eg, isolated necrotizing glomerulonephritis, isolated respiratory tract disease, or isolated orbital disease. Antineutrophil cytoplasmic autoantibody titers may be useful in modulating treatment regimens. There is in vitro evidence that antineutrophil cytoplasmic autoantibodies are directly involved in the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitides.

• Authors: J C Jennette, R J Falk
• Journal: Current opinion in rheumatology (Curr Opin Rheumatol) Vol. 4 Issue 1 Pg. 9-15 (Feb 1992) ISSN: 1040-8711 [Print] United States
• PMID: 1543669 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Autoantibodies
• Autoantigens
• Biomarkers

Topics

• Antibodies, Antineutrophil Cytoplasmic
• Autoantibodies
• Autoantigens
• Biomarkers
• Cytoplasm (immunology)
• Granulomatosis with Polyangiitis (drug therapy, immunology)
• Humans
• Neutrophils (immunology)
• Vasculitis (etiology, immunology)