[Serum sialyl-Tn antigen in colorectal cancer and its relationship to prognosis].

Abstract

Serum sialyl-Tn antigen level was studied in 117 cases of colorectal cancer. The positive rates for serum sialyl-Tn antigen were 23.1% in primary colorectal cancer. There is a significant correlation between the positive rates of serum sialyl-Tn antigen and liver metastases, peritoneal dissemination, or lymph node metastases. The survival rate for patients with sialyl-Tn antigen positive sera was lower than those with sialyl-Tn antigen negative. Among patients who underwent curative operation, patients with sialyl-Tn positive sera gave a recurrence rate of 35.7%, while those with sialyl-Tn negative sera recorded a recurrence rate of 14.7%. There is no correlation between the positive rates of serum sialyl-Tn antigen and DNA ploidy pattern. Serum sialyl-Tn antigen levels may be a useful indicator in projecting the prognosis of colorectal cancer.

• Authors: A Yamaguchi, Y Tukioka, S Fushida, Y Kurosaka, M Kanno, Y Yonemura, K Miwa, I Miyazaki
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 19 Issue 3 Pg. 349-53 (Mar 1992) ISSN: 0385-0684 [Print] Japan
• PMID: 1543361 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, Neoplasm
• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• DNA, Neoplasm
• sialosyl-Tn antigen

Topics

• Antigens, Neoplasm (blood)
• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor (blood)
• Colorectal Neoplasms (immunology, mortality, pathology)
• DNA, Neoplasm (analysis)
• Humans
• Ploidies
• Prognosis
• Survival Rate