The trial use of clozapine for abnormal involuntary movement disorders.

Abstract

Twelve patients with abnormal involuntary movement disorders were treated with clozapine in a double-blind, placebo-controlled trial. The cohort consisted of individuals with Gilles de la Tourette's syndrome, Huntington's disease, and atypical persistent dyskinesia that was drug induced. Two subjects were dropped from the protocol due to complications. Two patients with Huntington's disease showed a marked decrease in movements; other individuals obtained no significant therapeutic benefits. Seven of the 10 patients completing the trial experienced moderate or marked side effects.

• Authors: E D Caine, R J Polinsky, R Kartzinel, M H Ebert
• Journal: The American journal of psychiatry (Am J Psychiatry) Vol. 136 Issue 3 Pg. 317-20 (Mar 1979) ISSN: 0002-953X [Print] United States
• PMID: 154301 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Dibenzazepines
• Placebos
• Clozapine

Topics

• Adolescent
• Adult
• Child
• Clinical Trials as Topic
• Clozapine (adverse effects, therapeutic use)
• Dibenzazepines (therapeutic use)
• Double-Blind Method
• Drug Evaluation
• Dyskinesia, Drug-Induced (drug therapy)
• Female
• Humans
• Huntington Disease (drug therapy)
• Male
• Middle Aged
• Movement Disorders (drug therapy)
• Placebos
• Tourette Syndrome (drug therapy)