Reduction of urinary oxalate by combined calcium and citrate administration without increase in urinary calcium oxalate stone formers.

Abstract

Oxalic acid seems to play a far greater role in the formation of calcium oxalate stone than calcium. Three grams of calcium lactate and 3 g of sodium potassium citrate were administered to 46 urolithiasis patients, whose stones were mainly composed of calcium oxalate. Urinary oxalate level was reduced significantly without raising urinary calcium level by the administration of the two drugs for two weeks. The reduction of urinary oxalic acid was particularly remarkable in patients without hypercalciuria. The mechanism of action of these drugs was discussed.

• Authors: H Ito, F Suzuki, K Yamaguchi, Y Nishikawa, T Kotake
• Journal: Clinical nephrology (Clin Nephrol) Vol. 37 Issue 1 Pg. 14-8 (Jan 1992) ISSN: 0301-0430 [Print] Germany
• PMID: 1541059 (Publication Type: Journal Article)

Chemical References

• Calcium, Dietary
• Citrates
• Drug Combinations
• Oxalates
• Phosphorus
• Citric Acid
• Oxalic Acid
• Creatinine
• Magnesium
• Calcium

Topics

• Adult
• Aged
• Calcium (chemistry, therapeutic use, urine)
• Calcium, Dietary (administration & dosage)
• Citrates (therapeutic use)
• Citric Acid
• Creatinine (urine)
• Drug Combinations
• Female
• Humans
• Kidney Calculi (prevention & control, urine)
• Magnesium (urine)
• Male
• Middle Aged
• Oxalates (chemistry, urine)
• Oxalic Acid
• Phosphorus (urine)