Abstract |
Three oximes currently being evaluated for adoption as replacement nerve agent therapy by various countries were compared for therapeutic efficacy against the toxic organophosphate inhibitors soman and tabun under a standard set of conditions. These oximes together with PAM-Cl and toxogonin, were also compared for efficacy against GF, an agent weaponized by Iraq. The order of effectiveness against soman was HI-6 greater than HLö-7 greater than pyrimidoxime. HLö-7 was very effective against tabun poisoning while HI-6 and pyrimidoxime were of moderate value. Against GF, HI-6 and HLö-7 were extremely effective, toxogonin was moderately effective, and PAM-Cl and pyrimidoxime were the least effective. HI-6 provided a high level of protection against all of the agents tested as did HLö-7 to a slightly lesser degree. The other oximes suffered from their lack of effects against one or more of the organophosphates.
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Authors | P M Lundy, A S Hansen, B T Hand, C A Boulet |
Journal | Toxicology
(Toxicology)
Vol. 72
Issue 1
Pg. 99-105
( 1992)
ISSN: 0300-483X [Print] Ireland |
PMID | 1539175
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Chemical Warfare Agents
- Cholinesterase Inhibitors
- Organophosphates
- Organophosphorus Compounds
- Oximes
- Soman
- tabun
- cyclohexyl methylphosphonofluoridate
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Topics |
- Animals
- Chemical Warfare Agents
(toxicity)
- Cholinesterase Inhibitors
(toxicity)
- Guinea Pigs
- Lethal Dose 50
- Male
- Organophosphates
(toxicity)
- Organophosphorus Compounds
(toxicity)
- Oximes
(therapeutic use)
- Poisoning
(drug therapy)
- Soman
(toxicity)
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