Assessment of myocardial viability in rats: Evaluation of a new method using superparamagnetic iron oxide nanoparticles and Gd-DOTA at high magnetic field.
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| Abstract |
The aim of this study was to detect salvageable peri-infarction myocardium by MRI in rats after infarction, using with a double contrast agent (CA) protocol at 7 Tesla. Intravascular superparamagnetic iron oxide (SPIO) nanoparticles and an extracellular paramagnetic CA (Gd-DOTA) were used to characterize the peri-infarction zone, which may recover function after reperfusion occurs. Infarcted areas measured from T1-weighted (T1-w) images post Gd-DOTA administration were overestimated compared to histological TTC staining (52% +/- 3% of LV surface area vs. 40% +/- 3%, P=0.03) or to T2-w images post SPIO administration (41% +/- 4%, P=0.04), whereas areas measured from T2-w images post SPIO administration were not significantly different from those measured histologically (P=0.7). Viable and nonviable myocardium portions of ischemically injured myocardium were enhanced after diffusive Gd-DOTA injection. The subsequent injection of vascular SPIO nanoparticles enables the discrimination of viable peri-infarction regions by specifically altering the signal of the still-vascularized myocardium.
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| Authors | Catherine Chapon, Laurent Lemaire, Florence Franconi, Laurent Marescaux, Pierre Legras, Benoit Denizot, Jean-Jacques Le Jeune |
| Journal | Magnetic resonance in medicine (Magn Reson Med) Vol. 52 Issue 4 Pg. 932-6 (Oct 2004) ISSN: 0740-3194 [Print] United States |
| PMID | 15389960 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't) |
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