Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines.

Abstract

Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82-84% ee) from 2-octynal and their in vitro activity against cancer cells is described.

• Authors: Angelo de Fatima, Luciana Konecny Kohn, Márcia Aparecida Antônio, João Ernesto de Carvalho, Ronaldo Aloise Pilli
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 12 Issue 20 Pg. 5437-42 (Oct 15 2004) ISSN: 0968-0896 [Print] England
• PMID: 15388170 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Lactones
• argentilactone

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, toxicity)
• Cell Line, Tumor
• Female
• Humans
• Lactones (chemical synthesis, chemistry, toxicity)
• Male
• Stereoisomerism