Abstract |
Previous investigations have suggested that tumor necrosis factor-alpha ( TNF-alpha) can contribute to myocardial damage during ischemia-reperfusion. In the present study, we examined whether the cardioprotective effects of ligustrazine are related to inhibition of TNF-alpha production in the rat models of ischemia-reperfusion and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-induced myocardial injury. Ischemia for 20 min and reperfusion for 40 min caused a decline in cardiac function (left ventricular pressure, +/- d p/d t(max), heart rate and coronary flow) and an increase in the release of creatine kinase in coronary effluent and the content of TNF-alpha in myocardial tissues. Similarly, perfusion with DPPH (100 nM) for 30 min significantly decreased cardiac function, and increased the release of creatine kinase and the content of TNF-alpha. Ligustrazine at the concentration of 40 or 80 mg/L markedly improved cardiac function and reduced the release of creatine kinase and the content of TNF-alpha in myocardial tissues in hearts subjected to ischemia-reperfusion or DPPH perfusion. These results suggest that the cardioprotection afforded by ligustrazine is related to a reduction of TNF-alpha content by inhibition of free radical production in isolated rat hearts.
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Authors | Yuan Zhou, Chang-Ping Hu, Pan-Yue Deng, Han-Wu Deng, Yuan-Jian Li |
Journal | Planta medica
(Planta Med)
Vol. 70
Issue 9
Pg. 818-22
(Sep 2004)
ISSN: 0032-0943 [Print] Germany |
PMID | 15386191
(Publication Type: Journal Article)
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Chemical References |
- Biphenyl Compounds
- Cardiotonic Agents
- Picrates
- Plant Extracts
- Pyrazines
- Tumor Necrosis Factor-alpha
- 1,1-diphenyl-2-picrylhydrazyl
- tetramethylpyrazine
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Topics |
- Animals
- Biphenyl Compounds
- Cardiotonic Agents
(administration & dosage, pharmacology, therapeutic use)
- Ligusticum
- Male
- Myocardial Ischemia
(chemically induced, drug therapy, metabolism)
- Myocardial Reperfusion Injury
(prevention & control)
- Phytotherapy
- Picrates
- Plant Extracts
(administration & dosage, pharmacology, therapeutic use)
- Pyrazines
(administration & dosage, pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Tumor Necrosis Factor-alpha
(biosynthesis)
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