Abstract | INTRODUCTION: Although the exact mechanisms that lead to uveitis are not entirely known, the role of cytokines in the pathogenesis of this disease has been shown to be important. Prior studies described the presence of an array of cytokines in the intraocular fluid of patients with uveitis. Review of these studies indicate that Interleukin-6 (IL-6) is present, and animal data suggest the important role of IL-6 in the regulation of ophthalmologic immune responses. PURPOSE: METHODS: RESULTS:
IL-6 was higher in the vitreous of patients with uveitis compared to control samples (p = 0.0119). No TNF-alpha, IL-2, IL1-alpha or beta was detected. The levels of IL-6 did not correlate with a specific clinical diagnosis, but patients with pars planitis and panuveitis had the highest levels (p = 0.58) CONCLUSIONS:
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Authors | Victor L Perez, George N Papaliodis, David Chu, Fahd Anzaar, William Christen, C Stephen Foster |
Journal | Ocular immunology and inflammation
(Ocul Immunol Inflamm)
Vol. 12
Issue 3
Pg. 193-201
(Sep 2004)
ISSN: 0927-3948 [Print] England |
PMID | 15385196
(Publication Type: Journal Article, Review)
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Chemical References |
- Interleukin-1
- Interleukin-2
- Interleukin-6
- Tumor Necrosis Factor-alpha
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Topics |
- Enzyme-Linked Immunosorbent Assay
- Humans
- Interleukin-1
(metabolism)
- Interleukin-2
(metabolism)
- Interleukin-6
(metabolism)
- Pars Planitis
(immunology)
- Tumor Necrosis Factor-alpha
(metabolism)
- Uveitis, Posterior
(immunology)
- Vitreous Body
(immunology)
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