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Identification of monovinyl tripropionic acid porphyrins and metabolites from faeces of patients with hereditary coproporphyria by high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

Abstract
Harderoporphyrin (2-vinyl-4,6,7-tripropionic acid porphyrin) and its metabolites in faeces of patients with hereditary coproporphyria (HCP) have been separated and characterized by high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry (HPLC/ESI-Q-TOFMS/MS). The metabolites identified were 2-ethyl-4,6,7-tripropionic acid porphyrin, 2-hydro-4,6,7-tripropionic acid porphyrin, 2-methoxyethyl-4,6,7-tripropionic acid porphyrin and 2-acetyl-4,6,7-tripropionic acid porphyrin. Isomers of harderoporphyrin derived from isomerization of harderoporphyrinogen were also detected.
AuthorsMalcolm Danton, Chang Kee Lim
JournalRapid communications in mass spectrometry : RCM (Rapid Commun Mass Spectrom) Vol. 18 Issue 19 Pg. 2309-16 ( 2004) ISSN: 0951-4198 [Print] England
PMID15384152 (Publication Type: Comparative Study, Evaluation Studies, Journal Article, Validation Studies)
CopyrightCopyright 2004 John Wiley & Sons, Ltd.
Chemical References
  • Porphyrins
  • harderoporphyrin
Topics
  • Chromatography, High Pressure Liquid (methods)
  • Coproporphyria, Hereditary (diagnosis, metabolism)
  • Feces (chemistry)
  • Humans
  • Porphyrins (analysis, classification)
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spectrometry, Mass, Electrospray Ionization (methods)
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization (methods)

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