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The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice.

Abstract
The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated disturbances. Now, in male NMRI mice BPC 157 (10 pg intraperitoneally, 10 ng and 10 microg, intraperitoneally or intragastrically) (i) strongly opposed acute alcohol (4 g/kg intraperitoneally) intoxication (i.e., quickly produced and sustained anesthesia, hypothermia, increased ethanol blood values, 25% fatality, 90-min assessment period) given before or after ethanol, and (ii) when given after abrupt cessation of ethanol (at 0 or 3 or 7 h withdrawal time), attenuated withdrawal (assessed through 24 hours) after 20%-alcohol drinking (7.6 g/kg) through 13 days, with provocation on the 14th day.
AuthorsAlenka Boban Blagaic, Vladimir Blagaic, Zeljko Romic, Predrag Sikiric
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 499 Issue 3 Pg. 285-90 (Sep 24 2004) ISSN: 0014-2999 [Print] Netherlands
PMID15381050 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Peptide Fragments
  • Proteins
  • Ethanol
  • BPC 157
Topics
  • Alcohol Withdrawal Seizures (chemically induced, prevention & control)
  • Alcoholism (etiology, prevention & control)
  • Animals
  • Anti-Ulcer Agents (administration & dosage, pharmacology)
  • Dose-Response Relationship, Drug
  • Ethanol (administration & dosage, blood, toxicity)
  • Injections, Intraperitoneal
  • Male
  • Mice
  • Mice, Inbred Strains
  • Peptide Fragments (administration & dosage, pharmacology)
  • Proteins (administration & dosage, pharmacology)
  • Stomach (drug effects)
  • Substance Withdrawal Syndrome (etiology, prevention & control)
  • Time Factors

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