Inhibitors of types I and II dehydroquinase.

Inhibitors of varying potency have been developed for types I and II 3-dehydroquinate dehydratase (dehydroquinase), enzymes from the shikimate and quinate pathways that catalyse the dehydration of dehydroquinate to dehydroshikimate. These inhibitors have resulted from enzyme mechanistic studies and from the direct search for enzyme inhibitors with herbicidal, fungicidal or antimicrobial potential. This review discusses the design of the various inhibitors that have been produced so far and some structure-activity relationships. The majority of these inhibitors are based on dehydroquinate analogues, although some work has also been carried out on dehydroshikimate and bissulfonamides. Some discussion is also presented on advances in the synthesis of these types of compounds.
AuthorsChristine Le Sann, Mary A Gower, Andrew D Abell
JournalMini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 4 Issue 7 Pg. 747-56 (Sep 2004) ISSN: 1389-5575 [Print] Netherlands
PMID15379642 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Enzyme Inhibitors
  • Hydro-Lyases
  • 3-dehydroquinate dehydratase
  • Aspergillus nidulans (enzymology)
  • Enzyme Inhibitors (chemistry, pharmacology)
  • Hydro-Lyases (antagonists & inhibitors, physiology)
  • Molecular Structure
  • Mycobacterium tuberculosis (enzymology)
  • Salmonella typhimurium (enzymology)
  • Streptomyces coelicolor (enzymology)
  • Structure-Activity Relationship
  • Substrate Specificity

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