[Allogenic bone marrow transplantation in chronic myeloid leukemias].

Abstract

AIM:

To assess the role of allogenic bone marrow (ABM) transplantation in chronic myeloid leukemia (CML).

MATERIAL AND METHODS:

44 ABM transplantations were performed in 37 CML patients in the chronic phase and 7 patients in acceleration or blast crisis.

RESULTS:

A complete molecular remission was achieved in 26 (59%) patients: 67.6% after ABM transplantation in the chronic phase and only 14.3% after myelotransplantation in non-chronic phase. Follow-up was 8-150 months (median--59 months). Early lethality after ABM transplantation in the chronic phase was under 14%. A phase of the disease plays a key role in ABM transplantation. If it is made in a chronic phase, CML recurrence rate is low (in our series it was 14%), efficacy of donor's bone marrow lymphocyte transfusions is high. The second complete molecular remission was achieved in 3 of 4 cases of posttransplantation recurrences. Probability of maintenance of a complete remission after ABM transplantation in a chronic phase was 75%, recurrence-free survival--64%, uneventful survival 55% for 90 months.

CONCLUSION:

The experience of many years demonstrates high efficacy of ABM transplantation in the treatment of chronic myeloid leukemia. It promotes long-term molecular remission the maintenance of which did not require therapy in 65% patients.

• Authors: L S Liubimova, V G Savchenko, L P Mendeleeva, L A Kuz'mina, M V Anukhina, E O Gribanova, I A Demidova, A V Misiurin, O A Vinogradova, E V Domracheva, L P Poreshina, R M Kut'ina, A P Shpakova, A A Matveenko, N N Kalinin, E G Gemdzhian
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 76 Issue 7 Pg. 18-24 ( 2004) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Transplantatsiia allogennogo kostnogo mozga pri khronicheskom mieloleĭkoze.
• PMID: 15379122 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Bone Marrow Transplantation (methods)
• Disease-Free Survival
• Female
• Follow-Up Studies
• Genes, abl (genetics)
• Humans
• In Situ Hybridization, Fluorescence
• Karyotyping
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (genetics, mortality, surgery)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Remission Induction
• Transplantation, Homologous