Abstract | BACKGROUND: The radiosensitivity of the lung tissue limits the dose of radiation which can be delivered to tumors in the thoracic region. Radiation-induced lung damage implies the induction of numerous cytokines which form the basis for the multicellular interactions of the inflammatory and fibrogenic processes associated with radiation injury. It is of special clinical significance, how far local radiation induced cytokine production in the lung tissue may be reflected in increased cytokine blood levels in patients during radiotherapy and may predict the later development of radiation-induced lung damage. Another potential cause of increased cytokine levels in the blood of oncologic patients is the secretion of cytokines in the blood circulation by tumor specimens. METHODS: Published data on radiation-induced cytokine expression from experimental and clinical studies are reviewed. RESULTS AND CONCLUSION:
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Authors | Claudia E Rübe, H Peter Rodemann, Christian Rübe |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 180
Issue 9
Pg. 541-9
(Sep 2004)
ISSN: 0179-7158 [Print] Germany |
Vernacular Title | Die Bedeutung von Zytokinen für die radiogene Lungenreaktion. Experimentelle Grundlagen und klinische Relevanz. |
PMID | 15378184
(Publication Type: English Abstract, Journal Article, Review)
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Chemical References |
- Cytokines
- Radiation-Protective Agents
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Topics |
- Animals
- Clinical Trials as Topic
- Cytokines
(metabolism)
- Evidence-Based Medicine
(methods)
- Genetic Therapy
(methods)
- Humans
- Lung
(metabolism, radiation effects)
- Lung Diseases
(diagnosis, etiology, metabolism)
- Lung Injury
- Radiation Injuries
(diagnosis, etiology, metabolism, prevention & control)
- Radiation-Protective Agents
(therapeutic use)
- Radiotherapy
(adverse effects)
- Risk Assessment
(methods)
- Risk Factors
- Thoracic Neoplasms
(complications, diagnosis, radiotherapy, therapy)
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