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Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet.

Abstract
Tubeimoside 1, one of the new triterpenoid saponins from the bulb of Bolbostemma paniculatum (Maxim) Franquet, had an anti-inflammatory effect on mouse ear edema induced by arachidonic acid and 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, a potent anti-tumorigenic effect of tubeimoside 1 was observed in 2-stage carcinogenesis of mouse skin after oral administration as well as topical application. Thus, tubeimoside 1 appears to be a promising agent for cancer chemoprevention.
AuthorsL J Yu, R D Ma, Y Q Wang, H Nishino, J Takayasu, W Z He, M Chang, J Zhen, W S Liu, S X Fan
JournalInternational journal of cancer. Journal international du cancer (Int J Cancer) Vol. 50 Issue 4 Pg. 635-8 (Feb 20 1992) ISSN: 0020-7136 [Print] UNITED STATES
PMID1537629 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents, Phytogenic
  • Saponins
  • Triterpenes
  • tubeimoside I
  • Tetradecanoylphorbol Acetate
Topics
  • Administration, Topical
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents, Phytogenic (administration & dosage, pharmacology)
  • Body Weight (drug effects)
  • Female
  • Mice
  • Saponins (administration & dosage, pharmacology)
  • Skin Neoplasms (chemically induced, prevention & control)
  • Tetradecanoylphorbol Acetate (pharmacology)
  • Triterpenes

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