Abstract |
The product of the nm23-H1 gene, reported to be a metastatic suppressor gene, was recently identified as the nucleoside diphosphate ( NDP) kinase A, and was found to be overexpressed in several types of malignant tumors as compared with normal tissues. In order to determine whether NDP- kinase expression serves as a marker for metastatic potential and whether hyperproliferation of neoplastic cells would correlate with expression, we analyzed NDP- kinase levels and activity by immunohistochemical staining and by an enzymatic assay in 13 benign and 98 malignant breast-tissue specimens. Our results confirm that NDP- kinase expression increases in malignant cells of breast carcinomas, but cannot be considered as a biological marker of metastatic dissemination. No correlation was found between NDP- kinase activity and S phase, taken as an index of cell proliferation. Moreover, no correlation was observed between NDP- kinase activity and tumor size, histoprognostic index, estrogen receptors or progesterone receptors. The mechanism of over-expression of NDP in malignant cells and its role in tumor progression remain to be determined.
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Authors | X Sastre-Garau, M L Lacombe, M Jouve, M Véron, H Magdelénat |
Journal | International journal of cancer
(Int J Cancer)
Vol. 50
Issue 4
Pg. 533-8
(Feb 20 1992)
ISSN: 0020-7136 [Print] United States |
PMID | 1537618
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- NM23 Nucleoside Diphosphate Kinases
- Proteins
- Receptors, Estrogen
- Transcription Factors
- NME1 protein, human
- Nucleoside-Diphosphate Kinase
- Monomeric GTP-Binding Proteins
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Topics |
- Breast Neoplasms
(enzymology, pathology)
- Cell Division
- Genes, Tumor Suppressor
- Humans
- Lymphatic Metastasis
- Monomeric GTP-Binding Proteins
- NM23 Nucleoside Diphosphate Kinases
- Nucleoside-Diphosphate Kinase
- Proteins
(metabolism)
- Receptors, Estrogen
(metabolism)
- Transcription Factors
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